Peripheral arterial disease in patients with giant cell arteritis: a meta-analysis

Abstract

© 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd Aim: To investigate the association between giant cell arteritis (GCA) and risk of peripheral arterial disease (PAD). Methods: We conducted a systematic review and meta-analysis of observational cohort studies that reported relative risks, hazard ratios or standardized incidence ratios with 95% confidence comparing PAD risk in patients with GCA versus non-GCA subjects. Pooled risk ratios and 95% confidence intervals were calculated using a random-effect, generic inverse variance of DerSimonian and Laird. Results: Four studies with 9789 patients with GCA and 236 728 controls were identified and included in our data analysis. The pooled risk ratio of PAD among patients with GCA compared with controls was 1.88 (95% CI 1.04–3.41). The statistical heterogeneity was high with an I2of 89%. Conclusion: Our study demonstrated a statistically significant increased risk of PAD among patients with GCA.