Publication: Ankylosing spondylitis and risk of venous thromboembolism: A systematic review and meta-analysis
Issued Date
2016-11-01
Resource Type
ISSN
0974598X
09702113
09702113
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2-s2.0-84994646157
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Mahidol University
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SCOPUS
Bibliographic Citation
Lung India. Vol.33, No.6 (2016), 642-645
Suggested Citation
Patompong Ungprasert, Narat Srivali, Wonngarm Kittanamongkolchai Ankylosing spondylitis and risk of venous thromboembolism: A systematic review and meta-analysis. Lung India. Vol.33, No.6 (2016), 642-645. doi:10.4103/0970-2113.192862 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41020
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Title
Ankylosing spondylitis and risk of venous thromboembolism: A systematic review and meta-analysis
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Abstract
© 2016 Indian Chest Society | Published by Wolters Kluwer - Medknow Background: Several immune-mediated inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus have been linked to an increased risk of venous thromboembolism (VTE). However, the data on ankylosing spondylitis (AS) are limited. Methods: We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing the risk of VTE and possible pulmonary embolism (PE) in patients with AS versus non-AS participants. Pooled risk ratio and 95% confidence intervals were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results: Of 423 potentially relevant articles, three studies met our inclusion criteria and thus, were included in the data analysis. The pooled risk ratio of VTE in patients with AS was 1.60 (95% confidence interval: 1.05-2.44). The statistical heterogeneity of this study was high with an I2of 93%. Conclusion: Our study demonstrated a statistically significant increased VTE risk among patients with AS.