Publication: Mosaic structure of a multiple-drug-resistant, conjugative plasmid from Campylobacter jejuni
Issued Date
2005-06-01
Resource Type
ISSN
00664804
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2-s2.0-19544364887
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.49, No.6 (2005), 2454-2459
Suggested Citation
Warawadee Nirdnoy, Carl J. Mason, Patricia Guerry Mosaic structure of a multiple-drug-resistant, conjugative plasmid from Campylobacter jejuni. Antimicrobial Agents and Chemotherapy. Vol.49, No.6 (2005), 2454-2459. doi:10.1128/AAC.49.6.2454-2459.2005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16963
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Title
Mosaic structure of a multiple-drug-resistant, conjugative plasmid from Campylobacter jejuni
Author(s)
Abstract
Partial sequence analysis of a tet(O) plasmid from a multiple-drug- resistant clinical isolate of Campylobacter jejuni revealed 10 genes or pseudogenes encoding different aminoglycoside inactivating enzymes, transposase-like genes, and multiple unknown genes from a variety of pathogenic and commensal bacteria. The plasmid could be mobilized by a P incompatibility group plasmid into Escherichia coli, where it apparently integrated into the chromosome and expressed high-level resistance to multiple aminoglycoside antibiotics. This work provides new information about both the nature of drug resistance in C. jejuni and the ability of C. jejuni to exchange genes with other bacterial species. Copyright © 2005, American Society for Microbiology. All Rights Reserved.