Publication: Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand
Issued Date
2000-09-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0034280747
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.3 (2000), 493-497
Suggested Citation
Pongrama Ramasoota, Waranya Wongwit, Prasert Sampunachot, Komes Unnarat, Maeya Ngamying, Stefan B. Svenson Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.31, No.3 (2000), 493-497. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26190
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Title
Multiple Mutations in the rpoB gene of Mycobacterium Leprae strains from leprosy patients in Thailand
Abstract
A new finding is reported of multiple mutations in the rpoB gene of 9 Mycobacterium leprae strains from leprosy patients in Thailand, who did not respond to therapy even when rifampicin, the main drug in multi-drug therapy was used. By means of sequence analysis of 9 Thai M. leprae strains, various mutations in 289 bps of the rpoB gene revealed forms of mutation never before described, such as multiple mutations (ie, mutation at two, three, six, seven, eight and nine positions in the rpoB gene), most of which were point-mutation substitutions (a few of which were silent), and some insertions. This investigation demonstrates that mutation in the rpoB gene of M. leprae strains from Thailand involves more variety than previously reported for rpoB mutation patterns in rifampicin resistance M. leprae strains.