Publication: A multicenter study of clinical presentations and predictive factors for severe manifestation of dengue in adults
Issued Date
2018-01-01
Resource Type
ISSN
18842836
13446304
13446304
Other identifier(s)
2-s2.0-85047307263
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Mahidol University
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SCOPUS
Bibliographic Citation
Japanese Journal of Infectious Diseases. Vol.71, No.3 (2018), 239-243
Suggested Citation
Saranya Temprasertrudee, Vipa Thanachartwet, Varunee Desakorn, Jiraporn Keatkla, Wasun Chantratita, Sasisopin Kiertiburanakul A multicenter study of clinical presentations and predictive factors for severe manifestation of dengue in adults. Japanese Journal of Infectious Diseases. Vol.71, No.3 (2018), 239-243. doi:10.7883/yoken.JJID.2017.457 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47181
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Title
A multicenter study of clinical presentations and predictive factors for severe manifestation of dengue in adults
Abstract
© 2018, National Institute of Health. All rights reserved. Severe dengue is more prevalent in adults than in children. Our objectives were to determine the clinical presentations of dengue in adults and to identify predictive factors for severe dengue. A retrospective cohort study was performed in adults with dengue, as confirmed by a positive NS1 antigen test result. Patients were classified as with non-severe or severe dengue. A total of 357 patients were enrolled; 45.4% were men, with a median (interquartile range [IQR]) age of 27.9 (21.8–43.5) years. Of all patients, 28.3% had warning signs and 10.6% had severe dengue. Patients with severe dengue were significantly older (35.1 [26.2–50.6] vs. 26.7 [21.7–43.3] years, P = 0.010), immunocompromised (7.9% vs. 0.9%, P = 0.018), and had cough (29% vs. 16%, P = 0.046), hepatomegaly (10.5% vs. 3.1%, P = 0.050), impaired consciousness (5.3% vs. 0%, P = 0.011) or higher (IQR) alanine aminotransferase (ALT) level (151 [57–295] vs. 66 [37–114] U/L, P = 0.008). By multivariate analysis, having cough (odds ratio [OR], 8.07; 95% confidence interval [CI], 2.51–30.16, P = 0.001) and ALT > 120 U/L (OR, 3.51; 95% CI, 1.11–11.14, P = 0.033) were predictors of severe dengue. Early recognition of risk variables may be important for healthcare providers to appropriately manage dengue patients.