Publication: Dissemination of class i integron in acinetobacter baumannii isolated from ventilator-associated pneumonia patients and their environment
Issued Date
2009-11-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-76749138033
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.40, No.6 (2009), 1284-1292
Suggested Citation
Suntariya Sirichot, Pornphan Diraphat, Fuangfa Utrarachkij, Chanwit Tribuddharat, Kanokrat Siripanichgon Dissemination of class i integron in acinetobacter baumannii isolated from ventilator-associated pneumonia patients and their environment. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.40, No.6 (2009), 1284-1292. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27882
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Dissemination of class i integron in acinetobacter baumannii isolated from ventilator-associated pneumonia patients and their environment
Other Contributor(s)
Abstract
Multidrug resistant Acinetobacter baumannii has become the most common cause of health care-associated infections at Maharaj Nakhon Si Thammarat Hospital, Thailand. The objective of the study was to detect integrons using PCR-based method from 96 A. baumannii isolates from ventilator-associated pneumonia (VAP) patients and their environment. Antibiotic susceptibility was determined using a disk diffusion technique. Forty-six isolates exhibited integrase genes, with only class I and class II integron detected in 43 and 3 A. baumannii isolates, respectively. Twenty-seven of 52 clinical and 19 of 44 environmental isolates were integron-positive. Detection rate of integron-positive A. baumannii isolated from VAP patients increased from 25% to 83% over the 4 month study period. The majority (91%) of integron-positive A. baumannii showed resistance to 6 or more of 11 antibiotics tested and 72% of class I integronpositive isolates were imipenem-resistant. Thus, class I integron-positive A. baumannii had spread among the VAP patients and into hospital environment, the latter acting as reservoirs of potential pathogens possessing drug resistance genes.