Publication: Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
Issued Date
2012-10-01
Resource Type
ISSN
14711753
09546634
09546634
Other identifier(s)
2-s2.0-84866295887
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Dermatological Treatment. Vol.23, No.5 (2012), 385-392
Suggested Citation
Ganniga Pumthong, Pravit Asawanonda, Supenya Varothai, Vorapicha Jariyasethavong, Daranporn Triwongwaranat, Puan Suthipinittharm, Kornkanok Ingkaninan, Pimporn Leelapornpisit, Neti Waranuch Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study. Journal of Dermatological Treatment. Vol.23, No.5 (2012), 385-392. doi:10.3109/09546634.2011.568470 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14615
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Title
Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
Abstract
Background: Several botanically derived agents are available for the treatment of male-pattern baldness. Objective: The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5a-reductase and 5% minoxidil in the treatment of androgenetic alopecia. Methods: Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding. Results: There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study. Conclusion: In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth. © 2012 Informa Healthcare USA on behalf of Informa UK Ltd.