Publication: Issues related to recent dengue vaccine development
Issued Date
2011-12-01
Resource Type
ISSN
13494147
13488945
13488945
Other identifier(s)
2-s2.0-84863826505
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Mahidol University
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SCOPUS
Bibliographic Citation
Tropical Medicine and Health. Vol.39, No.4 SUPPL. (2011), 63-71
Suggested Citation
Eiji Konishi Issues related to recent dengue vaccine development. Tropical Medicine and Health. Vol.39, No.4 SUPPL. (2011), 63-71. doi:10.2149/tmh.2011-S01 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12164
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Title
Issues related to recent dengue vaccine development
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Abstract
Dengue fever (DF) and dengue heemorrhagic fever (DHF) are mosquito-transmitted diseases of global importance. Despite significant research efforts, no approved vaccines or antiviral drugs against these diseases are currently available. This brief article reviews the status of dengue vaccine development, with particular emphasis on the vaccine strategies in more advanced stages of evaluation; these include traditional attenuation, chimerization and engineered attenuation. Several aspects of these vaccine design strategies, including concerns about vaccine candidates inducing infection-enhancing antibodies, are also presented. © 2011 by The Japanese Society of Tropical Medicine.