Publication: INTRAVENOUS AMODIAQUINE AND ORAL AMODIAQUINE/ERYTHROMYCIN IN THE TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA
Issued Date
1985-10-12
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ISSN
01406736
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2-s2.0-0022403153
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Mahidol University
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SCOPUS
Bibliographic Citation
The Lancet. Vol.326, No.8459 (1985), 805-808
Suggested Citation
Sornchai Looareesuwan, Nicholas J. White, Yupin Benjasurat, Rodney E. Phillips, Juntra Karbwang, Panosri Attanath, David A. Warrell INTRAVENOUS AMODIAQUINE AND ORAL AMODIAQUINE/ERYTHROMYCIN IN THE TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA. The Lancet. Vol.326, No.8459 (1985), 805-808. doi:10.1016/S0140-6736(85)90796-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30859
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Title
INTRAVENOUS AMODIAQUINE AND ORAL AMODIAQUINE/ERYTHROMYCIN IN THE TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA
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Abstract
In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h. All patients were clinically cured-mean fever clearance time 37·8 h (range 24-60), mean parasite clearance time 64·9 h (18-164). There were no serious toxic effects. 33 patients aged over 5 years with uncomplicated falciparum malaria were given oral amodiaquine dihydrochloride (mean total dose 41 mg base/kg over 3 days) combined with erythromycin estolate (mean dose 48 mg base/kg daily for 5 days). 2 patients failed to respond. In the other 31 patients mean fever clearance time was 55·9 h (range 10-104) and mean parasite clearance time was 65·4 h (40-120). In both studies, more than half the patients followed-up had recurrent parasitaemia but reinfection could not be excluded. Parasites isolated from 18 patients were highly resistant to chloroquine in vitro. © 1985.