Publication: Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5
Issued Date
2021-05-01
Resource Type
ISSN
18811469
00218820
00218820
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2-s2.0-85099443090
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Antibiotics. Vol.74, No.5 (2021), 359-362
Suggested Citation
Takuya Yoshioka, Yasuhiro Igarashi, Takushi Namba, Shohei Ueda, Ivy Grace Umadhay Pait, Takuya Nihira, Shigeru Kitani Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5. Journal of Antibiotics. Vol.74, No.5 (2021), 359-362. doi:10.1038/s41429-020-00404-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78965
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Title
Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5
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Abstract
In our screening program for new biologically active compounds, a new polyene macrolide, lavencidin (1), along with known compound RKGS-A2215A (2), was isolated from the fermentation broth of Streptomyces lavendulae FRI-5 by changing the composition of liquid medium normally used for the strain. Their structures were elucidated by spectral methods (high-resolution fast-atom bombardment mass spectrometry (HRFABMS) and nuclear magnetic resonance (NMR)). Compound 1 includes a conjugated pentaene moiety together with six hydroxy groups and a carboxylic acid as a side chain. Lavencidin (1) showed moderate growth-inhibitory activity against yeast and was cytotoxic against human cancer cell lines with low-micromolar IC50 values.