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Synthesis and biological evaluation of simplified analogs of lophocladine B as potential antitumor agents

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dc.contributor.authorSewan Theeramunkongen_US
dc.contributor.authorOpa Vajraguptaen_US
dc.contributor.authorChawannuch Mudjupaen_US
dc.contributor.otherThammasat Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMahasarakham Universityen_US
dc.date.accessioned2018-12-11T02:31:46Z
dc.date.accessioned2019-03-14T08:04:25Z
dc.date.available2018-12-11T02:31:46Z
dc.date.available2019-03-14T08:04:25Z
dc.date.issued2016-12-01en_US
dc.description.abstract© 2016, Springer Science+Business Media New York. In this study, two series of simplified isoquinolines deriving from lophocladine B were synthesized and evaluated for their antitumor activity. Suzuki-Miyaura and Sharpelss-Fokin reactions were employed to synthesize 26 compounds. Two compounds (25 and 27) showed to be cytotoxic with IC50 values of 10 µM on hepatic cancer cells and 13 µM on cervical cancer cells, respectively. Further studies on their mechanism of action showed that compound 27 mediated cytotoxicity through apoptosis induction.en_US
dc.identifier.citationMedicinal Chemistry Research. Vol.25, No.12 (2016), 2959-2964en_US
dc.identifier.doi10.1007/s00044-016-1717-5en_US
dc.identifier.issn15548120en_US
dc.identifier.issn10542523en_US
dc.identifier.other2-s2.0-84987625036en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/43358
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84987625036&origin=inwarden_US
dc.subjectChemistryen_US
dc.titleSynthesis and biological evaluation of simplified analogs of lophocladine B as potential antitumor agentsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84987625036&origin=inwarden_US

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