Publication: Immuno-histochemical expression of p53 protein and iNOS in odontogenic cysts
Issued Date
2009-07-01
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ISSN
01252208
01252208
01252208
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2-s2.0-67749110281
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.92, No.7 (2009), 952-960
Suggested Citation
Sopee Poomsawat, Jirapa Punyasingh, Paisarn Vejchapipat Immuno-histochemical expression of p53 protein and iNOS in odontogenic cysts. Journal of the Medical Association of Thailand. Vol.92, No.7 (2009), 952-960. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28014
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Title
Immuno-histochemical expression of p53 protein and iNOS in odontogenic cysts
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Abstract
Objective: The present study investigated the expression of p53 protein and iNOS in odontogenic keratocysts (OKCs), dentigerous cysts (DCs) and radicular cysts (RCs) and determined the correlation of these 2 proteins within each cyst type. Material and Method: p53 and iNOS in epithelial lining cells were analyzed in 20 OKCs, 20 DCs and 20 RCs using immuno-histochemistry. The percentage of positive cells was assessed and presented as mean ± SD. The correlation between the expressions of these 2 proteins in each cyst was carried out using Spearman correlation analysis. Results: p53 was found in 95% of OKCs, 50% of DCs and 65% of RCs. p53-positive cells in OKCs (12.2 ± 8.8%) were significantly higher than those in DCs (1.4 ± 3.2%) and RCs (1.3 ± 2.4%). iNOS was found in all examined lesions. Statistically, iNOS-positive cells in RCs (86.9 + 9.9%) were lower than those in OKCs (94.8 ± 3.5%) and DCs (96.1 ± 4.4%). No correlation between the expression of p53 and iNOS was found in each cyst. Conclusion: p53 was over expressed in OKCs compared with other lesions. RCs showed the lowest expression of iNOS.