Publication: Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability
Issued Date
2017-08-01
Resource Type
ISSN
15734803
00222461
00222461
Other identifier(s)
2-s2.0-85018942033
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Materials Science. Vol.52, No.16 (2017), 9249-9261
Suggested Citation
Weerakanya Maneeprakorn, Lionel Maurizi, Hathainan Siriket, Tuksadon Wutikhun, Tararaj Dharakul, Heinrich Hofmann Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability. Journal of Materials Science. Vol.52, No.16 (2017), 9249-9261. doi:10.1007/s10853-017-1098-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42586
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Title
Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability
Abstract
© 2017, Springer Science+Business Media New York. A simple, rapid, reproducible, and scalable method for generating highly stable cross-linked superparamagnetic nanohybrids was developed. Pre-coating of superparamagnetic iron oxide nanoparticle surfaces with a biocompatible polymer, hydroxy polyvinyl alcohol (PVA-OH) prior to cross-linking with silica precursor resulted in improved stability, uniform morphologies and allows for further surface functionalization. The obtained magnetic nanohybrids contain a non-porous silica layer, are monodisperse (size 50.0 ± 3.7 nm), and show colloidal stability applicable for biomedical applications (pH 7.35–7.45) with long shelf life (>9 months). In vitro studies indicate that as-prepared nanohybrids are non-cytotoxic and highly robust toward endosomal/lysosomal conditions, with no particle dissolution evident for up to 42 days. As a demonstration of the potential utility of these nanohybrids in medical diagnostic applications (e.g., MRI), surface functionalization with folic acid resulted in particle recognition and affinity to folate receptor-positive cervix (HeLa) cells. Accordingly, the facile development of these non-toxic, stable cross-linked magnetic nanohybrids, with the added benefit of scalable preparation, should serve as an entry point for the further development of safer, target specific, MRI contrast agents for cancer diagnosis.