Publication: Outcomes of follicle-stimulating hormone priming and nonpriming in in vitro maturation of oocytes in infertile women with polycystic ovarian syndrome: A single-blinded randomized study
Issued Date
2015-01-01
Resource Type
ISSN
1423002X
03787346
03787346
Other identifier(s)
2-s2.0-84926418584
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Gynecologic and Obstetric Investigation. Vol.79, No.3 (2015), 153-159
Suggested Citation
Roungsin Choavaratana, Isarin Thanaboonyawat, Pitak Laokirkkiat, Japarath Prechapanich, Singpetch Suksompong, Orawan Mekemaharn, Somsin Petyim Outcomes of follicle-stimulating hormone priming and nonpriming in in vitro maturation of oocytes in infertile women with polycystic ovarian syndrome: A single-blinded randomized study. Gynecologic and Obstetric Investigation. Vol.79, No.3 (2015), 153-159. doi:10.1159/000367660 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36727
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Outcomes of follicle-stimulating hormone priming and nonpriming in in vitro maturation of oocytes in infertile women with polycystic ovarian syndrome: A single-blinded randomized study
Other Contributor(s)
Abstract
© 2014 S. Karger AG, Basel. Background/Aims: Follicle-stimulating hormone (FSH) priming has been studied in in vitro matured oocytes for oocyte maturation rate, embryo quality, and pregnancy rate with discouraging results. This study aimed to initiate FSH stimulation later, i.e. on day 6, to prolong natural endometrial priming and promote oocyte maturation. Methods: Forty polycystic ovarian syndrome (PCOS) patients were enrolled into a single, blinded (investigator), randomized, controlled study, and randomly allocated to group 1 (no FSH priming) or group 2 (day 6 recombinant FSH priming). Oocytes were retrieved after human chorionic gonadotropin injection on day 10. After 27 or 51 h of incubation, only mature oocytes were denuded and fertilized by intracytoplasmic sperm injection. Two day 3 embryos were transferred in most patients. Rates of oocyte maturation, cleavage, and pregnancy were compared. Results: The oocyte maturation rates within 51 h were 62.6 and 72.7% in groups 1 and 2, respectively (p < 0.01). The embryo cleavage rate was significantly higher in group 2 than in group 1 (77.3 vs. 63.6%, p < 0.05). The pregnancy rate was higher in group 1 than in group 2 (50 vs. 30%, p > 0.05). Conclusion: FSH priming is beneficial for promotion of the maturation and quality of oocytes, leading to a higher embryo cleavage rate and lower rate of pregnancy loss.