Publication: Association of premature ventricular complexes and risk of ischemic stroke: A systematic review and meta-analysis
Issued Date
2021-02-01
Resource Type
ISSN
19328737
01609289
01609289
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2-s2.0-85097603680
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Cardiology. Vol.44, No.2 (2021), 151-159
Suggested Citation
Pongprueth Rujirachun, Phuuwadith Wattanachayakul, Prawut Phichitnitikorn, Nipith Charoenngam, Jakrin Kewcharoen, Arjbordin Winijkul Association of premature ventricular complexes and risk of ischemic stroke: A systematic review and meta-analysis. Clinical Cardiology. Vol.44, No.2 (2021), 151-159. doi:10.1002/clc.23531 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78494
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Title
Association of premature ventricular complexes and risk of ischemic stroke: A systematic review and meta-analysis
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Abstract
Recent studies have suggested that patients with premature ventricular complexes (PVCs) may have a higher risk of ischemic stroke. However, the data are limited and inconclusive. We conducted a systematic review and meta-analysis to investigate the association between PVCs and the risk of ischemic stroke. A comprehensive literature review was conducted by searching for published articles indexed in MEDLINE and EMBASE databases from inception through September 25, 2020, to identify studies that compared the risk of ischemic stroke between patients with PVCs and individuals without PVCs. Pooled risk ratio (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method of Dersimonian and Laird. A total of four observational studies (2 prospective and 2 retrospective cohort studies) with 42 677 participants met the eligibility criteria and were included in the meta-analysis. We found that patients with PVCs have a significantly higher risk of ischemic stroke than individuals without PVCs with the pooled RR of 1.31 (95% CI, 1.07–1.60, I2 = 43%). From our systematic review and meta-analysis, we found that PVCs are associated with a higher risk of ischemic stroke. Whether this association is causal and how it should be addressed in clinical practice require further investigations.