Publication: A scoring system for the classification of β-thalassemia/Hb E disease severity
3
Issued Date
2008-06-01
Resource Type
ISSN
10968652
03618609
03618609
Other identifier(s)
2-s2.0-44349122895
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Hematology. Vol.83, No.6 (2008), 482-484
Suggested Citation
Orapan Sripichai, Wattanan Makarasara, Thongperm Munkongdee, Chutima Kumkhaek, Issarang Nuchprayoon, Ampaiwan Chuansumrit, Suporn Chuncharunee, Nawarat Chantrakoon, Piathip Boonmongkol, Pranee Winichagoon, Suthat Fucharoen A scoring system for the classification of β-thalassemia/Hb E disease severity. American Journal of Hematology. Vol.83, No.6 (2008), 482-484. doi:10.1002/ajh.21130 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/19661
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Title
A scoring system for the classification of β-thalassemia/Hb E disease severity
Abstract
β-Thalassemia intermediate patients show a remarkable clinical heterogeneity. We examined the phenotypic diversity of 950 β-thalassemia/Hb E patients in an attempt to construct a system for classifying disease severity. A novel scoring system based on six independent parameters, hemoglobin level, age at disease presentation, age at receiving first blood transfusion, requirement for transfusion, spleen size, and growth and development, was able to separate patients into three distinctive severity categories: mild, moderate, and severe courses. This system, therefore, can increase the accuracy of studies of genotype-phenotype interactions and facilitate decisions for appropriate patient management. © 2008 Wiley-Liss, Inc.