Publication: Short report: Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis
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Issued Date
2011-06-01
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00029637
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2-s2.0-79958740023
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.84, No.6 (2011), 858-861
Suggested Citation
Direk Limmathurotsakul, Vanaporn Wuthiekanun, Gumphol Wongsuvan, Sukanya Pangmee, Premjit Amornchai, Prapit Teparrakkul, Nittaya Teerawattanasook, Nicholas P J Day, Sharon J. Peacock Short report: Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. American Journal of Tropical Medicine and Hygiene. Vol.84, No.6 (2011), 858-861. doi:10.4269/ajtmh.2011.10-0618 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/12042
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Title
Short report: Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis
Abstract
Melioidosis, a bacterial infection caused by Burkholderia pseudomallei, is notoriously difficult to cure despite appropriate antimicrobial therapy and has a mortality rate of up to 40%. We demonstrate that a blood culture positive for B. pseudomallei taken at the end of the first and/or second week after hospitalization for melioidosis is a strong prognostic factor for death (adjusted odds ratio = 4.2, 95% confidence interval = 2.1-8.7, P < 0.001 and adjusted odds ratio = 2.6, 95% confidence interval = 1.1-6.0, P = 0.03, respectively). However, repeat cultures of respiratory secretions, urine, throat swabs, or pus/surface swabs provide no prognostic information. This finding highlights the need for follow-up blood cultures in patients with melioidosis. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.