Publication: Normalized coagulation markers and anticoagulation proteins in children with severe β-thalassemia disease after stem cell transplantation
Issued Date
2012-06-01
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ISSN
18792472
00493848
00493848
Other identifier(s)
2-s2.0-84861335596
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Mahidol University
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SCOPUS
Bibliographic Citation
Thrombosis Research. Vol.129, No.6 (2012), 765-770
Suggested Citation
Nongnuch Sirachainan, Jaruwan Thongsad, Samart Pakakasama, Suradej Hongeng, Ampaiwan Chuansumrit, Praguywan Kadegasem, Arjit Tirakanjana, Napaporn Archararit, Somtawin Sirireung Normalized coagulation markers and anticoagulation proteins in children with severe β-thalassemia disease after stem cell transplantation. Thrombosis Research. Vol.129, No.6 (2012), 765-770. doi:10.1016/j.thromres.2011.07.046 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14772
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Title
Normalized coagulation markers and anticoagulation proteins in children with severe β-thalassemia disease after stem cell transplantation
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Abstract
The hypercoagulable state is well recognized in patients with severe β-thalassemia disease. One of the mechanisms of chronic hypercoagulable state is the abnormal expression of phosphatidylserine on red blood cells (RBC). This study aimed to determine the coagulable state in patients with severe β-thalassemia disease following successful stem cell transplantation (SCT). Subjects were classified into three groups: normal controls (NC), β-thalassemia disease receiving regular transfusion (Thal-RT) and β-thalassemia disease post SCT (Thal-SCT). Sixty eight subjects, aged 3-17 years, consisting of 21 NC, 28 Thal-RT and 19 Thal-SCT were enrolled. After SCT, the annexin V level in Thal-SCT was normalized. At the median follow-up time of 70.3 (50.9-84.2) months after SCT, the levels of coagulation markers (thrombin antithrombin complex, prothrombin fragment and D-dimer) and anticoagulation proteins (protein C, S and antithrombin activities) returned to the levels similar to controls. © 2011 Elsevier Ltd. All rights reserved.