Publication: Levels of Serum Interleukin-6 and Tumor Necrosis Factor in Postsplenectomized Thalassemic Patients
Issued Date
1997-09-01
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ISSN
01252208
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2-s2.0-0005376562
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.80, No.SUPPL. 1 (1997)
Suggested Citation
Suporn Chuncharunee, Napaporn Archararit, Phongjan Hathirat, Umaporn Udomsubpayakul, Vichai Atichartakarn Levels of Serum Interleukin-6 and Tumor Necrosis Factor in Postsplenectomized Thalassemic Patients. Journal of the Medical Association of Thailand. Vol.80, No.SUPPL. 1 (1997). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18086
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Title
Levels of Serum Interleukin-6 and Tumor Necrosis Factor in Postsplenectomized Thalassemic Patients
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Abstract
Levels of serum interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were studied in 34 nonsplenectomized thalassemic patients (Thal/nonsplenec), 43 postsplenectomized thalassemic patients (Thal/postsplenec), 13 splenectomized non-thalassemic patients (nonThal/ postsplenec) and 18 normal control by enzyme linked immunosorbent assay method. Serum IL-6 concentration in Thal/postsplenec was significantly increased when compared with Thal/ nonsplenec and normal volunteers (3.55±2.47 pg/ml vs 2.38±2.31 pg/ml, p=0.036 and 3.55±2.47 pg/ml vs 2.66±0.45 pg/ml, p=0.028, respectively). This study also demonstrated that TNF-α value in Thal/postsplenec was drastically increased above normal control level (15.8±4.86 pg/ml vs 9.16±2.18 pg/ml, p=0.001) and the level was statistically significantly higher than that in Thal/ nonsplenec (15.5±4.86 pg/ml vs 9.96±5.19 pg/ml, p=0.001). There was a trend toward increasing of cytokine levels in Thal/postsplenec with higher platelet count although no correlation was observed. This study addresses the possible role of IL-6 and TNF-α in the pathogenesis of reactive thrombocytosis in Thal/postsplenec.