Publication: Renal magnesium wasting and tubular dysfunction in leptospirosis
Issued Date
2008-03-01
Resource Type
ISSN
14602385
09310509
09310509
Other identifier(s)
2-s2.0-42449137968
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nephrology Dialysis Transplantation. Vol.23, No.3 (2008), 952-958
Suggested Citation
Sookkasem Khositseth, Niwatchai Sudjaritjan, Paiboon Tananchai, Sompong Ong-Ajyuth, Visith Sitprija, Visith Thongboonkerd Renal magnesium wasting and tubular dysfunction in leptospirosis. Nephrology Dialysis Transplantation. Vol.23, No.3 (2008), 952-958. doi:10.1093/ndt/gfm698 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19758
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Renal magnesium wasting and tubular dysfunction in leptospirosis
Abstract
Background. Tubulo-interstitial nephritis is the main cause of acute renal injury in leptospirosis. The aim of this study was to evaluate renal tubular function and excretion of solutes in leptospirosis patients during a recent outbreak of leptospirosis in Nan province, Thailand. Methods. Clinical manifestations were recorded and routine laboratory tests were performed upon admission. Renal tubular functions including tubular reabsorption of phosphate (TRP), fractional excretion of magnesium (FEMg), urinary calcium to creatinine ratio (Uca/cr), urine N-acetyl-β-d glucosaminidase (NAG) and urine β2-microglobulin were serially monitored during 2 weeks after admission. Results. A total of 20 leptospirosis patients were recruited. Nine (45%) patients had acute renal failure (ARF). Increased urine NAG and β2-microglobulin, which indicate proximal tubular dysfunction, were demonstrated in all 20 (100%) patients. Fifteen (75%) patients had hypermagnesuria, whereas 10 (50%) patients had decreased TRP. Renal magnesium (Mg) and phosphate (P) wasting caused hypomagnesaemia and hypophosphataemia in nine and three patients with ARF, respectively. These abnormal findings significantly improved within 2 weeks after admission. Conclusions. We conclude that renal Mg and P wasting commonly occur in patients with leptospirosis. The measurement of Mg and P levels in both serum and urine of leptospirosis patients, especially those with ARF, is therefore highly recommended. © The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.