Publication: A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans
| dc.contributor.author | Yongwimon Lenbury | en_US |
| dc.contributor.author | Pornsarp Pornsawad | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-06-21T08:09:54Z | |
| dc.date.available | 2018-06-21T08:09:54Z | |
| dc.date.issued | 2005-03-01 | en_US |
| dc.description.abstract | The present work develops and analyses a model system of delay-differential equations which describes the core dynamics of the stress-responsive hypothalamus-pituitary-adrenal axis. This neuroendocrine ensemble exhibits prominent pulsatile secretory patterns governed by nonlinear and time-delayed feedforward and feedback signal interchanges. Formulation and subsequent bifurcation analysis of the model provide a qualitative and mathematical frame work for a better understanding of the delayed responsive mechanisms as well as the dynamic variations in different pathological situations. © The Author 2005. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All Rights Reserved. | en_US |
| dc.identifier.citation | Mathematical Medicine and Biology. Vol.22, No.1 (2005), 15-33 | en_US |
| dc.identifier.doi | 10.1093/imammb/dqh020 | en_US |
| dc.identifier.issn | 14778599 | en_US |
| dc.identifier.other | 2-s2.0-17144425726 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/16369 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=17144425726&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Environmental Science | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.subject | Mathematics | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Neuroscience | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | A delay-differential equation model of the feedback-controlled hypothalamus-pituitary-adrenal axis in humans | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=17144425726&origin=inward | en_US |