Publication: Investigation of basement membrane proteins in a case of granular cell ameloblastoma
Issued Date
2012-04-01
Resource Type
ISSN
20493169
16742818
16742818
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2-s2.0-84864200799
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Oral Science. Vol.4, No.1 (2012), 45-49
Suggested Citation
Puangwan Lapthanasupkul, Sopee Poomsawat, Jira Chindasombatjaroen Investigation of basement membrane proteins in a case of granular cell ameloblastoma. International Journal of Oral Science. Vol.4, No.1 (2012), 45-49. doi:10.1038/ijos.2012.9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14084
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Title
Investigation of basement membrane proteins in a case of granular cell ameloblastoma
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Abstract
Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported. Histopathological features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor follicles. After treatment by partial mandibulectomy, the patient showed a good prognosis without recurrence in a 2-year follow-up. To characterize the granular cells in ameloblastoma, we examined the expression of basement membrane (BM) proteins, including collagen type IV, laminins 1 and 5 and fibronectin using immunohistochemistry. Except for the granular cells, the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study, whereas the granular cells showed strong positivity to laminins 1 and 5 and fibronectin. The increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma. © 2012 WCSS. All rights reserved.