Publication: Molecular Epidemiology and Mechanisms of Carbapenem Resistance of Acinetobacter spp. In Asia and Oceania
Issued Date
2015-01-01
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ISSN
19318448
10766294
10766294
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2-s2.0-84937785521
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Mahidol University
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SCOPUS
Bibliographic Citation
Microbial Drug Resistance. Vol.21, No.4 (2015), 424-434
Suggested Citation
Witchuda Kamolvit, Hanna E. Sidjabat, David L. Paterson Molecular Epidemiology and Mechanisms of Carbapenem Resistance of Acinetobacter spp. In Asia and Oceania. Microbial Drug Resistance. Vol.21, No.4 (2015), 424-434. doi:10.1089/mdr.2014.0234 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36161
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Title
Molecular Epidemiology and Mechanisms of Carbapenem Resistance of Acinetobacter spp. In Asia and Oceania
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Abstract
© Mary Ann Liebert, Inc. 2015. Acinetobacter baumannii is emerging as a pathogen that is commonly involved in nosocomial infections. A. baumannii has exhibited the ability to develop multidrug resistance (MDR), including resistance to carbapenems, the last-line class of antibiotics to treat these infections. In particular, MDR A. baumannii International Clone (IC) 2 has disseminated worldwide causing substantial problems in hospitals, including in Asia and Oceania. The global spread of this clonal lineage emphasizes the importance of tracking molecular epidemiology to obtain greater understanding of the population dynamics of A. baumannii. Carbapenem resistance in A. baumannii occurs mainly as a result of acquisition of OXA-type carbapenemase genes, and to some extent by acquisition of metallo-β-lactamase genes. The acquisition of carbapenemase genes, particularly the bla<inf>OXA-23</inf>, bla<inf>OXA-40</inf>, and bla<inf>OXA-58</inf>, by specific clonal lineages may be one of the attributes responsible for the relative homogeneity of the MDR A. baumannii population.