Publication:
A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos

Issued Date

2003-05-01

Resource Type

Article

ISSN

00359203

DOI

10.1016/S0035-9203(03)90165-9

Other identifier(s)

2-s2.0-4444234983

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.97, No.3 (2003), 343-344

Suggested Citation

Mayfong Mayxay, Rattanaxay Phetsouvanh, Samlane Phompida, Paul N. Newton, Maniphone Khanthavong, Bouakham Vannachone, Alan Brockman, Nicholas J. White A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.97, No.3 (2003), 343-344. doi:10.1016/S0035-9203(03)90165-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20907

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Title

A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos

Author(s)

Mayfong Mayxay
 Rattanaxay Phetsouvanh
 Samlane Phompida
 Paul N. Newton
 Maniphone Khanthavong
 Bouakham Vannachone
 Alan Brockman
 Nicholas J. White

Other Contributor(s)

National University of Laos
 Mahosot Hospital
 Parasitology and Entomology
 John Radcliffe Hospital
 Mahidol University
 Shoklo Malaria Research Unit

Abstract

Between June and October 2000 we conducted the first randomized trial in Laos comparing chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated Plasmodium falciparum malaria (n = 29, 42-d follow-up, age > 5 years). The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently. © 2003 Royal Society of Tropical Medicine and Hygiene.

Keyword(s)

Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/20907

Collections

Scopus 2001-2005