Southeast Asian Journal of Tropical Medicine and Public Health. Vol.11, No.2 (1980), 256-261
Suggested Citation
U. Vongsthongsri, S. Tharavanij Susceptibility of Salmonella typhi to chloramphenicol, ampicillin and cotrimoxazole. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.11, No.2 (1980), 256-261. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11120
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Susceptibility of Salmonella typhi to chloramphenicol, ampicillin and cotrimoxazole
Salmonella typhi isolated from the patients admitted to the Hospital for Tropical Diseases, Bangkok, were tested by the tube dilution method and the disc diffusion method against chloramphenicol, ampicillin and cotrimoxazole. Forty-five percent of the S.typhi were resistant to chloramphenicol (MIC≥50 microgram/ml) while 5% were resistant to ampicillin (MIC≥12.5 microgram/ml). Only 1% of the S.typhi was found to be resistant to cotrimoxazole (MIC≥168 microgram of trimethoprim + sulfamethoxazole per ml.) Based on these results, the drug of choice for typhoid fever would be cotrimoxazole, especially when drug sensitivity test is not immediately available.
