Publication: Pharmacokinetics of primaquine in G6PD deficient and G6PD normal patients with vivax malaria
Issued Date
1994-01-01
Resource Type
ISSN
18783503
00359203
00359203
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2-s2.0-0028331832
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, No.2 (1994), 220-222
Suggested Citation
Kesara Na Bangchang, Wasana Songsaeng, Aurathai Thanavibul, Preecha Choroenlarp, Juntra Karbwang Pharmacokinetics of primaquine in G6PD deficient and G6PD normal patients with vivax malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.88, No.2 (1994), 220-222. doi:10.1016/0035-9203(94)90306-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9575
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Title
Pharmacokinetics of primaquine in G6PD deficient and G6PD normal patients with vivax malaria
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Abstract
The pharmacokinetics of primaquine have been studied in 13 G6PD normal and 13 G6PD deficient Thai male patients with Plasmodium vivax malaria who were given daily doses of 15 mg of primaquine over 14 d, following a full course of chloroquine. After the first dose (15 mg), primaquine underwent rapid absorption. Mean values (SD in parentheses) of maximum plasma concentration of 57.7 (7.7) vs. 55.7 (7.4) ng/mL were reached at 2.2 (0.6) vs. 2.2 (0.6) h, for the G6PD deficient and G6PD normal groups, respectively. Thereafter, drug levels declined rapidly and monoexponentially with a t 1/2λ of 6.4(1.9) vs. 6.3 (2.7) h. The respective mean values (SD in parentheses) for MRT, AUC 0–α Cl/f, and V z f were 6.8 (0.4) vs. 6.8 (0.5) h, 0.547 (0.070) vs. 0.521(0.090)μg/h/mL, 8.54 (0.37) vs. 8.97 (1.46) mL/min/kg and 4.8 (1.7) vs. 5.1 (1.2) L/kg. There was no differencein the plasma concentrations or pharmacokinetics of primaquine between patients with normal G6PD and G6PD deficiency. In the G6PD deficient group, no relationship between the severity of haemolysis ( < 20% or > 20% haemolysis) and the concentrations/pharmacokinetics of primaquine was observed. © 1994 Oxford University Press.