Publication:
Intratypic variation of herpes simplex virus type 2 isolates detected by monoclonal antibodies against viral glycoproteins

Issued Date

1990-03-01

Resource Type

Article

ISSN

14328798
03048608

DOI

10.1007/BF01310625

Other identifier(s)

2-s2.0-0025002145

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Archives of Virology. Vol.115, No.1-2 (1990), 89-100

Suggested Citation

P. Bhattarakosol, C. Yoosook, A. Cross Intratypic variation of herpes simplex virus type 2 isolates detected by monoclonal antibodies against viral glycoproteins. Archives of Virology. Vol.115, No.1-2 (1990), 89-100. doi:10.1007/BF01310625 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15958

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Title

Intratypic variation of herpes simplex virus type 2 isolates detected by monoclonal antibodies against viral glycoproteins

Author(s)

P. Bhattarakosol
 C. Yoosook
 A. Cross

Other Contributor(s)

Mahidol University
 Medical Research Council

Abstract

Monoclonal antibodies (MAbs) to herpes simplex virus (HSV) glycoproteins gD, gG, gB, and gE were used to analyze antigenic variations of 128 genital HSV-2 isolates by an indirect enzyme-linked immunosorbent assay (ELISA). Isolates were considered significantly different from the standard HSV-2 strain 186 when their optical density (OD) in ELISA was less than half that of strain 186. This criterion gave 30 patterns of reactivity among the genital HSV-2 isolates. The MAbs to gB, gG, and 2 of the gD antibodies reacted with more than 90% of the isolates, suggesting that these MAbs recognized highly conserved epitopes. However, the gE MAb reacted with only 47% of the isolates, and one of the gD antibodies with only 39%. Thus, HSV-2 can readily tolerate modifications in some parts of the gD and gE molecules while remaining infectious. © 1990 Springer-Verlag.

Keyword(s)

Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/15958

Collections

Scopus 1969-1990