Publication: Intratypic variation of herpes simplex virus type 2 isolates detected by monoclonal antibodies against viral glycoproteins
Issued Date
1990-03-01
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ISSN
14328798
03048608
03048608
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2-s2.0-0025002145
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Virology. Vol.115, No.1-2 (1990), 89-100
Suggested Citation
P. Bhattarakosol, C. Yoosook, A. Cross Intratypic variation of herpes simplex virus type 2 isolates detected by monoclonal antibodies against viral glycoproteins. Archives of Virology. Vol.115, No.1-2 (1990), 89-100. doi:10.1007/BF01310625 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15958
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Title
Intratypic variation of herpes simplex virus type 2 isolates detected by monoclonal antibodies against viral glycoproteins
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Abstract
Monoclonal antibodies (MAbs) to herpes simplex virus (HSV) glycoproteins gD, gG, gB, and gE were used to analyze antigenic variations of 128 genital HSV-2 isolates by an indirect enzyme-linked immunosorbent assay (ELISA). Isolates were considered significantly different from the standard HSV-2 strain 186 when their optical density (OD) in ELISA was less than half that of strain 186. This criterion gave 30 patterns of reactivity among the genital HSV-2 isolates. The MAbs to gB, gG, and 2 of the gD antibodies reacted with more than 90% of the isolates, suggesting that these MAbs recognized highly conserved epitopes. However, the gE MAb reacted with only 47% of the isolates, and one of the gD antibodies with only 39%. Thus, HSV-2 can readily tolerate modifications in some parts of the gD and gE molecules while remaining infectious. © 1990 Springer-Verlag.