Publication: A Bleeding Syndrome in Infants due to Acquired Prothrombin Complex Deficiency: A Survey of 93 Affected Infants
Issued Date
1977-01-01
Resource Type
ISSN
19382707
00099228
00099228
Other identifier(s)
2-s2.0-0017642961
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Pediatrics. Vol.16, No.11 (1977), 992-998
Suggested Citation
P. Bhanchet, S. Tuchinda, P. Hathirat, P. Visudhiphan, N. Bhamaraphavati, S. Bukkavesa A Bleeding Syndrome in Infants due to Acquired Prothrombin Complex Deficiency: A Survey of 93 Affected Infants. Clinical Pediatrics. Vol.16, No.11 (1977), 992-998. doi:10.1177/000992287701601106 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10327
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Title
A Bleeding Syndrome in Infants due to Acquired Prothrombin Complex Deficiency: A Survey of 93 Affected Infants
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Abstract
A bleeding syndrome due to severe prothrombin complex deficiency is reported in 93 infants. Most were breast fed (98 per cent), aged 2 weeks to 1 year and there were no serious preceding or associated diseases. Hemor rhagic diathesis, pallor and mild hepatomegaly were the major manifesta tions. The incidence of intracr nial bleeding was strikingly high (63 per cent) particularly with subdural and subarachnoid hemorrhage. Acute onset, short course and rapid clinical and laboratory improvement after vitamin K therapy were observed. Mortality rate was 35 per cent but has been reduced to 17 per cent since 1969. The location of bleeding, prompt diagnosis and early treatment are the major factors affecting prognosis. Severe prothrombin complex deficiency due to vitamin K deficiency ac counted for the pathogenesis of bleeding. Possible causes of vitamin K deficiency were discussed but definite conclusions could not be drawn. © 1977, Sage Publications. All rights reserved.