Publication: Magnetic nanocellulose alginate hydrogel beads as potential drug delivery system
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Issued Date
2018-10-15
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ISSN
18790003
01418130
01418130
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2-s2.0-85049338908
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Biological Macromolecules. Vol.118, (2018), 640-648
Suggested Citation
Jagadeesen Supramaniam, Rohana Adnan, Noor Haida Mohd Kaus, Rani Bushra Magnetic nanocellulose alginate hydrogel beads as potential drug delivery system. International Journal of Biological Macromolecules. Vol.118, (2018), 640-648. doi:10.1016/j.ijbiomac.2018.06.043 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/45029
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Title
Magnetic nanocellulose alginate hydrogel beads as potential drug delivery system
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Abstract
© 2018 Elsevier B.V. Magnetic nanocellulose alginate hydrogel beads are produced from the assembly of alginate and magnetic nanocellulose (m-CNCs) as a potential drug delivery system. The m-CNCs were synthesized from cellulose nanocrystals (CNCs) that were isolated from rice husks (RH) by co-precipitation method and were incorporated into alginate-based hydrogel beads with the aim of enhancing mechanical strength and regulating drug release behavior. Ibuprofen was chosen as a model drug. The prepared CNCs, m-CNCs and the alginate hydrogel beads were characterized by various physicochemical techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and vibrating sample magnetometer studies (VSM). Besides the magnetic property, the presence of m-CNCs increased the integrity of the alginate hydrogel beads and the swelling percentage. The drug release study exhibited a controlled release profiles and based on the drug release data, the drug release mechanism was analyzed and discussed based on mathematical models such as Korsmeyer-Peppas and Peppas-Sahlin.