Publication: Incidence of anemia in leprosy patients treated with dapsone
Issued Date
1984-12-01
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ISSN
01252208
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2-s2.0-0021745207
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.67, No.7 (1984), 404-408
Suggested Citation
S. Puavilai, S. Chutha, N. Polnikorn, P. Timpatanapong, P. Tasanapradit, S. Charuwichitratana, A. Boonthanom, H. Wongwaisayawan Incidence of anemia in leprosy patients treated with dapsone. Journal of the Medical Association of Thailand. Vol.67, No.7 (1984), 404-408. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30645
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Title
Incidence of anemia in leprosy patients treated with dapsone
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Abstract
Fifty-seven patients with different types of leprosy treated with dapsone 50-100 mg per day were evaluated in regard to the frequency, onset and etiology of anemia. Fifty-one patients had normal G-6-PD, six patients had complete deficiency of G-6-PD. Significant anemia developed in 40 cases out of 51 patients with normal G-6-PD (P<0.05). The onset of significant anemia in this group was one month after dapsone administration and continued throughout the course of treatment for one year. The methemoglobin level rose significantly (P < 0.01) in correlation with the dose of dapsone administered. Seventeen patients had hemolysis, 13 had Heinz bodies and one had positive direct Coombs' test. Hemolytic anemia developed in 5 out of 6 patients with complete deficiency of G-6-PD, but not severe enough to necessitate discontinuation of treatment.