Publication: Anaplerotic roles of pyruvate carboxylase in mammalian tissues
Issued Date
2006-04-01
Resource Type
ISSN
15691632
1420682X
1420682X
Other identifier(s)
2-s2.0-33646579537
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Mahidol University
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SCOPUS
Bibliographic Citation
Cellular and Molecular Life Sciences. Vol.63, No.7-8 (2006), 843-854
Suggested Citation
S. Jitrapakdee, A. Vidal-Puig, J. C. Wallace Anaplerotic roles of pyruvate carboxylase in mammalian tissues. Cellular and Molecular Life Sciences. Vol.63, No.7-8 (2006), 843-854. doi:10.1007/s00018-005-5410-y Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23056
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Title
Anaplerotic roles of pyruvate carboxylase in mammalian tissues
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Abstract
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-γ, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the 'pyruvate/malate cycle' to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression. © Birkhäuser Verlag, 2006.