Publication:
Efficacy and plasma concentrations of indinavir when boosted with ritonavir in human immunodeficiency virus-infected Thai children

Issued Date

2007-01-01

Resource Type

Article

ISSN

08913668

DOI

10.1097/01.inf.0000247140.94669.1b

Other identifier(s)

2-s2.0-33846004830

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Pediatric Infectious Disease Journal. Vol.26, No.1 (2007), 86-88

Suggested Citation

Nottasorn Plipat, Tim R. Cressey, Nirun Vanprapar, Kulkanya Chokephaibulkit Efficacy and plasma concentrations of indinavir when boosted with ritonavir in human immunodeficiency virus-infected Thai children. Pediatric Infectious Disease Journal. Vol.26, No.1 (2007), 86-88. doi:10.1097/01.inf.0000247140.94669.1b Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25062

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Title

Efficacy and plasma concentrations of indinavir when boosted with ritonavir in human immunodeficiency virus-infected Thai children

Author(s)

Nottasorn Plipat
 Tim R. Cressey
 Nirun Vanprapar
 Kulkanya Chokephaibulkit

Other Contributor(s)

Mahidol University
 Harvard School of Public Health

Abstract

We evaluated 19 children using 220-300 mg/m of indinavir (IDV) boosted with 100 mg ritonavir (RTV) (n = 12) or full-dose RTV (n = 7). Geometric mean (GM) (90% confidence interval, CI) of IDV Ctrough in children who took IDV with 100 mg RTV (n = 12) was 0.17 (0.06-0.50) mg/L. For children who took IDV with full-dosage RTV, GM (90% CI) was 0.40 (0.10-1.61) mg/L. C2hours were less than 10 mg/L in all subjects. Eighteen children had good virologic response. This report demonstrates that smaller IDV dosages given with RTV provide efficacious plasma concentrations and can be safely used. © 2007 Lippincott Williams & Wilkins, Inc.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/123456789/25062

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Scopus 2006-2010