Publication: Comparative assessment of the intracellular survival of the Burkholderia pseudomallei bopC mutant
Issued Date
2013-08-01
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ISSN
19763794
12258873
12258873
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2-s2.0-84883407644
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Microbiology. Vol.51, No.4 (2013), 522-526
Suggested Citation
Varintip Srinon, Sunsiree Muangman, Nithima Imyaem, Veerachat Muangsombut, Natalie R. Lazar Adler, Edouard E. Galyov, Sunee Korbsrisate Comparative assessment of the intracellular survival of the Burkholderia pseudomallei bopC mutant. Journal of Microbiology. Vol.51, No.4 (2013), 522-526. doi:10.1007/s12275-013-2557-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/31890
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Title
Comparative assessment of the intracellular survival of the Burkholderia pseudomallei bopC mutant
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Abstract
Burkholderia pseudomallei, the causative agent of melioidosis, is a Gram-negative saprophytic bacterium capable of surviving within phagocytic cells. To assess the role of BopC (a type III secreted effector protein) in the pathogenesis of B. pseudomallei, a B. pseudomallei bopC mutant was used to infect J774A.1 macrophage-like cells. The bopC mutant showed significantly reduced intracellular survival in infected macrophages compared to wild-type B. pseudomallei. In addition, the bopC mutant displayed delayed escape from endocytic vesicles compared with the wild-type strain. This indicates that BopC is important, and at least in part, needed for intracellular survival of B. pseudomallei. © 2013 The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg.