Publication: Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand.
Accepted Date
2008-11-06
Issued Date
2008-11-06
Copyright Date
2008
Resource Type
Language
eng
ISSN
1475-2875 (electronic)
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Carrara VI, Phyo AP, Nwee P, Soe M, Htoo H, Arunkamomkiri J. et al. Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand. Malar J. 2008 Nov 6;7:233.
Suggested Citation
Carrara, Verena I, Phyo, Aung P, Nwee, Paw, Soe, Ma, Htoo, Hsar, Jaruwan Arunkamomkiri, Pratap Singhasivanon, ประตาป สิงหศิวานนท์, Nosten, François Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand.. Carrara VI, Phyo AP, Nwee P, Soe M, Htoo H, Arunkamomkiri J. et al. Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand. Malar J. 2008 Nov 6;7:233.. doi:10.1186/1475-2875-7-233 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/792
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Title
Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand.
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Abstract
BACKGROUND: The use of artemisinin derivatives has increased exponentially with
the deployment of artemisinin combination therapy (ACT) in all malarious areas.
They are highly effective and are considered safe, but in animal studies
artemisinin derivatives produce neurotoxicity targeting mainly the auditory and
vestibular pathways. The debate remains as to whether artemisinin derivatives
induce similar toxicity in humans.
METHODS: This prospective study assessed the effects on auditory function of a
standard 3-day oral dose of artesunate (4 mg/kg/day) combined with mefloquine (25
mg/kg) in patients with acute uncomplicated falciparum malaria treated at the
Shoklo Malaria Research Unit, on the Thai-Burmese border. A complete auditory
evaluation with tympanometry, audiometry and auditory brainstem responses (ABR)
was performed before the first dose and seven days after initiation of the
antimalarial treatment.
RESULTS: Complete auditory tests at day 0 (D0) and day 7 (D7) were obtained for
93 patients. Hearing loss (threshold > 25 dB) on admission was common (57%) and
associated with age only. No patient had a threshold change exceeding 10 dB
between D0 and D7 at any tested frequency. No patient showed a shift in Wave III
peak latency of more than 0.30 msec between baseline and D7.
CONCLUSION: Neither audiometric or the ABR tests showed clinical evidence of
auditory toxicity seven days after receiving oral artesunate and mefloquine.