Publication: Biomarker discovery in glomerular diseases using urinary proteomics
Issued Date
2008-12-01
Resource Type
ISSN
18628346
Other identifier(s)
2-s2.0-67449141120
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proteomics - Clinical Applications. Vol.2, No.10-11 (2008), 1413-1421
Suggested Citation
Visith Thongboonkerd Biomarker discovery in glomerular diseases using urinary proteomics. Proteomics - Clinical Applications. Vol.2, No.10-11 (2008), 1413-1421. doi:10.1002/prca.200800036 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18804
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Biomarker discovery in glomerular diseases using urinary proteomics
Author(s)
Other Contributor(s)
Abstract
Renal biopsy remains the gold standard test for definitive diagnosis of glomerular diseases. This invasive procedure; however, has a potential risk for serious complications and is contraindicated in some patients. It is therefore essential to search for noninvasive biomarkers for the diagnosis and prognosis of glomerular diseases. The urine is the most appropriate sample for biomarker discovery in glomerular diseases. Urinary proteomics has thus gained a wide acceptance and has been extensively applied to this area. This review focuses mainly on applications of proteomic technologies to urinary proteome profiling for biomarker discovery in various glomerular diseases, including diabetic nephropathy, IgA nephropathy, membranous nephropathy, focal segmental glomerulosclerosis, primary membranoproliferative glomerulonephritis, lupus nephritis, antiglomerular basement membrane disease, minimal change disease, and pediatric nephrotic syndrome. Recent findings from these studies are summarized and discussed. These data clearly underline the great promise of urinary proteomics in biomarker discovery for glomerular diseases. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.