Publication: Detection of BCR/ABL fusion gene in CML: a preliminary report.
Issued Date
1995-12-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0029436682
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.26 Suppl 1, (1995), 197-200
Suggested Citation
B. Rerkamnuaychoke, D. Kangwanpong, S. Jootar, C. Puranakanitstha Detection of BCR/ABL fusion gene in CML: a preliminary report.. The Southeast Asian journal of tropical medicine and public health. Vol.26 Suppl 1, (1995), 197-200. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17363
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Detection of BCR/ABL fusion gene in CML: a preliminary report.
Other Contributor(s)
Abstract
The BCR/ABL fusion gene in 31 patients with chronic myeloid leukemia (CML) was detected by RT/PCR. In 18 cases of Ph' positive patients, 13 had BCR 3/ABL II rearrangement, 1 had BCR 2/ABL II rearrangement and 4 had both rearrangements. One case with complex translocation: 46,XY,t(9;9;22), had BCR 3/ABL II rearrangement. In 8 cases of Ph' negative patients, 4 had BCR 3/ABL II rearrangement, 3 had both rearrangements while 1 had no BCR/ABL rearrangement. Interestingly, in 4 patients who had no cytogenetic result, we could observe BCR 3/ABL II rearrangement in 3 cases and both rearrangements in 1 case. The results suggest that this procedure is sensitive and independent of the presence or absence of an identifiable Ph' chromosome.