Publication:
Hypovitaminosis D in healthy children in Central Thailand: prevalence and risk factors

dc.contributor.authorKanit Reesukumalen_US
dc.contributor.authorKotchamol Manonukulen_US
dc.contributor.authorOrathai Jirapongsananuruken_US
dc.contributor.authorWijittra Krobtrakulchaien_US
dc.contributor.authorSithikan Hanyongyuthen_US
dc.contributor.authorSomruedee Chatsiricharoenkulen_US
dc.contributor.authorBusadee Pratumviniten_US
dc.contributor.otherMahidol University. Faculty of Medicine Siriraj Hospital. Department of Clinical Pathologyen_US
dc.date.accessioned2017-08-04T06:48:07Z
dc.date.available2017-08-04T06:48:07Z
dc.date.created2017-08-04
dc.date.issued2015
dc.description.abstractBackground: There are limited data regarding the prevalence and risk factors relating to hypovitaminosis D in children of Thailand, a tropical country with abundant sunlight. The objective of this study was to assess the prevalence of hypovitaminosis D and examine factors associated with hypovitaminosis D in school-aged children in Bangkok, Thailand – a centrally located capital city. Methods: This cross-sectional study evaluated 159 healthy children (33.3% boys and 66.7% girls), aged 6 to 12 years, in Bangkok, Thailand (located at 13.45°N). Fasting plasma samples were examined for total 25-hydroxyvitamin D [25(OH)D] using electrochemiluminescence immunoassay. Demographic characteristics (age, sex, household income), past medical history (birth weight, allergic diseases, hospitalization), amount of sun exposure, anthropometric data, and selected biochemical tests were used to investigate for factors associated with hypovitaminosis D. Results: Overall, the mean ± SD level of plasma 25(OH)D was 64.0 ± 15.1 nmol/L. Hypovitaminosis D (< 75 nmol/L) was presented in 79.2% of subjects. Of these, the prevalence of vitamin D insufficiency and vitamin D deficiency were 59.7% and 19.5%, respectively. In univariate analysis, children with hypovitaminosis D (< 75 nmol/L) had a higher mean body mass index (BMI) percentile than the vitamin D-sufficient group (56.7 ± 33.9 vs. 42.6 ± 36.0; P-value = 0.04). Plasma PTH levels in the children with hypovitaminosis D were significantly higher than in the children with normal levels of vitamin D (4.34 ± 1.38 vs 3.78 ± 1.25 pmol/L; P-value = 0.04). In multivariate analysis, high BMI percentile and high PTH concentration were the parameters associated with 25(OH)D level < 75 nmol/L. Conclusion: The prevalence of hypovitaminosis D in healthy Thai children is very high, despite their exposure to sunlight, and that prevalence increases in children with a high BMI percentile. As a result, a formal recommendation for vitamin D supplementation in Thai children should be considered.en_US
dc.identifier.citationBMC Public Health. Vol. 15, (2015), 248en_US
dc.identifier.doi10.1186/s12889-015-1588-6
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/2665
dc.language.isoengen_US
dc.rightsMahidol Universityen_US
dc.rights.holderBioMed Centralen_US
dc.subjectOpen Access articleen_US
dc.subject25-Hydroxyvitamin Den_US
dc.subjectHypovitaminosis Den_US
dc.subjectVitamin D insufficiencyen_US
dc.subjectVitamin D deficiencyen_US
dc.subjectChildrenen_US
dc.titleHypovitaminosis D in healthy children in Central Thailand: prevalence and risk factorsen_US
dc.typeResearch Articleen_US
dspace.entity.typePublication

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