Publication: Tumor necrosis factor in septicemic melioidosis
Issued Date
1992-01-01
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-0026543829
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.165, No.3 (1992), 561-564
Suggested Citation
Y. Suputtamongkol, D. Kwiatkowski, D. A B Dance, W. Chaowagul, N. J. White Tumor necrosis factor in septicemic melioidosis. Journal of Infectious Diseases. Vol.165, No.3 (1992), 561-564. doi:10.1093/infdis/165.3.561 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22312
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Title
Tumor necrosis factor in septicemic melioidosis
Other Contributor(s)
Abstract
Plasma concentrations of the cytokine tumor necrosis factor (TNF) were measured serially in 91 patients suspected of having septicemic melioidosis. This was confirmed in 55. TNF was detectable in admission plasma (TNF0) in 3 of 15 survivors of septicemic melioidosis and 21 of 26 fatal cases (P <.001). The median (range) TNF0concentration in melioidosis patients who died was 96 (1-4774) pg/ml, and the median time to death was 25 (5-672) h. TNF0was inversely correlated with the lowest mean arterial pressure in the succeeding 12 h (Spearman’s rank correlation coefficient =.67, 2P <.001). Three patterns of TNF plasma concentrations were evident: relatively constant values between 100 and 500 pg/ml (n = 7), high admission concentrations (>1000 pg/ml) associated with early death (n = 4), and an apparent pulse release after treatment, with peak values > 1000 pg/ml, which then declined with a mean (SD) apparent half-time of 131 (50) min (n = 8). Further studies are necessary to determine whether TNF contributes to lethality in melioidosis. © 1992 Oxford University Press.