Publication: Treatment of uncomplicated and severe malaria during pregnancy
Issued Date
2018-04-01
Resource Type
ISSN
14744457
14733099
14733099
Other identifier(s)
2-s2.0-85044172122
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Mahidol University
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SCOPUS
Bibliographic Citation
The Lancet Infectious Diseases. Vol.18, No.4 (2018), e133-e146
Suggested Citation
Umberto D'Alessandro, Jenny Hill, Joel Tarning, Christopher Pell, Jayne Webster, Julie Gutman, Esperanca Sevene Treatment of uncomplicated and severe malaria during pregnancy. The Lancet Infectious Diseases. Vol.18, No.4 (2018), e133-e146. doi:10.1016/S1473-3099(18)30065-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46813
Research Projects
Organizational Units
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Title
Treatment of uncomplicated and severe malaria during pregnancy
Other Contributor(s)
Universidade Eduardo Mondlane
Medical Research Council Laboratories Gambia
London School of Hygiene & Tropical Medicine
Centers for Disease Control and Prevention
Liverpool School of Tropical Medicine
Mahidol University
Nuffield Department of Clinical Medicine
University of Amsterdam
Amsterdam Institute for Global Health and Development
Manhiça Health Research Center (CISM)
Medical Research Council Laboratories Gambia
London School of Hygiene & Tropical Medicine
Centers for Disease Control and Prevention
Liverpool School of Tropical Medicine
Mahidol University
Nuffield Department of Clinical Medicine
University of Amsterdam
Amsterdam Institute for Global Health and Development
Manhiça Health Research Center (CISM)
Abstract
© 2018 Elsevier Ltd Over the past 10 years, the available evidence on the treatment of malaria during pregnancy has increased substantially. Owing to their relative ease of use, good sensitivity and specificity, histidine rich protein 2 based rapid diagnostic tests are appropriate for symptomatic pregnant women; however, such tests are less appropriate for systematic screening because they will not detect an important proportion of infections among asymptomatic women. The effect of pregnancy on the pharmacokinetics of antimalarial drugs varies greatly between studies and class of antimalarial drugs, emphasising the need for prospective studies in pregnant and non-pregnant women. For the treatment of malaria during the first trimester, international guidelines are being reviewed by WHO. For the second and third trimester of pregnancy, results from several trials have confirmed that artemisinin-based combination treatments are safe and efficacious, although tolerability and efficacy might vary by treatment. It is now essential to translate such evidence into policies and clinical practice that benefit pregnant women in countries where malaria is endemic. Access to parasitological diagnosis or appropriate antimalarial treatment remains low in many countries and regions. Therefore, there is a pressing need for research to identify quality improvement interventions targeting pregnant women and health providers. In addition, efficient and practical systems for pharmacovigilance are needed to further expand knowledge on the safety of antimalarial drugs, particularly in the first trimester of pregnancy.