Publication: Anti-acne inducing bacteria activity and α-mangostin content of Garcinia mangostana fruit rind extracts from different provenience
Issued Date
2009-01-01
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01253395
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2-s2.0-67650889286
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Mahidol University
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SCOPUS
Bibliographic Citation
Songklanakarin Journal of Science and Technology. Vol.31, No.1 (2009), 41-47
Suggested Citation
Werayut Pothitirat, Mullika Traidej Chomnawang, Wandee Gritsanapan Anti-acne inducing bacteria activity and α-mangostin content of Garcinia mangostana fruit rind extracts from different provenience. Songklanakarin Journal of Science and Technology. Vol.31, No.1 (2009), 41-47. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28398
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Anti-acne inducing bacteria activity and α-mangostin content of Garcinia mangostana fruit rind extracts from different provenience
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Abstract
The fruit rind of Garcinia mangostana Linn. has been traditionally used for treatment of skin infection, wounds, dysentery, and diarrhea. α-Mangostin, a major constituent of the fruit rind, was reported to possess a strong inhibitory effect against Propionibacterium acnes and Staphylococcus epidermidis, which is involved in acne development. This study was conducted to quantitative analyze the content of α-mangostin in the fruit rind of this plant collected from 13 locations in the South and East of Thailand by validated TLC-densitometric method. Antibacterial activity against P. acnes and S. epidermidis of the extracts was also determined. α-Mangostin contents in the fruit rinds and in the 95 % ethanolic extracts were found in the ranges of 3.39-5.68 and 11.83-23.11 % dry weight, respectively. The samples from the South showed higher contents of α-mangostin (average 17.64 % w/w in the extract and 4.85 % w/w in the dried powder) than the eastern samples. The MIC values of all extracts against P. acnes and S. epidermidis were in the range of 7.81-15.63 and 15.63-31.25 μg/mL, respectively, while the MBC values were in the range of 15.63-31.25 and 62.50-125.00 μg/mL, respectively. The antibacterial activity and αmangostin content of the samples from different locations were significantly different (p<0.05). The average MIC and MBC values indicate that the samples from the South of Thailand (MIC = 13.02 μg/mL, MBC = 15.63 μg/mL for P. acne and MIC = 23.44 μg/mL, MBC =8 3.33 μg/mL for S. epidermidis) promoted stronger antibacterial effect than the samples from the East. The results suggest that the α-mangostin content in the extract of G. mangostana fruit rind correlates with the anti-acne inducing bacteria activity. The fruit rinds of G. mangostana cultivated in the South seemed to be the appropriate source in terms of higher α-mangostin content and better anti-acne property.