Publication: Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells
Issued Date
2017-08-18
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ISSN
15327914
01635581
01635581
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2-s2.0-85024483600
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Mahidol University
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SCOPUS
Bibliographic Citation
Nutrition and Cancer. Vol.69, No.6 (2017), 862-872
Suggested Citation
Dunyaporn Trachootham, Pimjai Chingsuwanrote, Penkhair Yoosadiang, Duangsamon Mekkriangkrai, Tanapat Ratchawong, Nicha Buraphacheep, Siripa Kijanukul, Sumrit Saekhow, Orawan Pongpitchayadej, Kittituch Vongvachvasin, Paknisa Sittikornpaiboon, Siriporn Tuntipopipat Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells. Nutrition and Cancer. Vol.69, No.6 (2017), 862-872. doi:10.1080/01635581.2017.1339097 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41806
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Title
Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells
Abstract
© 2017 Taylor & Francis Group, LLC. Suitable diet for cancer survivors remains an unresolved challenge. Increased glucose utilization is a hallmark of various cancers. Therefore, alternative carbohydrate supplying normal tissue but retarding cancer growth is needed. This study investigated the effect of sugar alcohols on the proliferation of oral cancer cells compared to nontransformed cells and explored the mechanism. Six oral squamous cell carcinoma (CAL-27, FaDu, SCC4, SCC9, SCC15, and SCC25) and one nontransformed oral keratinocyte (OKF6/TERT2) lines were cultured in media containing 1 mg/ml glucose and 5.8 mg/ml xylitol or sorbitol, yielding equal energy input to control group (4.5 mg/ml glucose). Partial substitution of glucose with sugar alcohols especially xylitol significantly suppressed proliferation of oral cancer but not nontransformed cells. Despite the addition of isocaloric quantities of the sugars, cancer cells exposed to low glucose plus xylitol had retarded ATP generation and decreased activity of phosphofructokinase (PFK), the rate-limiting enzyme in glycolysis. Furthermore, D-xylulose, its key metabolic intermediate, enhanced the anticancer effect of xylitol. These findings suggested a selective anticancer activity of xylitol and the potential mechanism involving inhibition of glucose utilization. Partial substitution of glucose with xylitol may be a proper nutrient for oral cancer survivors, deserving further investigation in animal and clinical settings.