Publication: Enterococcus faecalis enhances cell proliferation through hydrogen peroxide-mediated epidermal growth factor receptor activation
1
Issued Date
2012-10-01
Resource Type
ISSN
10985522
00199567
00199567
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2-s2.0-84867584659
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Mahidol University
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SCOPUS
Bibliographic Citation
Infection and Immunity. Vol.80, No.10 (2012), 3545-3558
Suggested Citation
Kanitsak Boonanantanasarn, Ann Lindley Gill, YoonSing Yap, Vijayvel Jayaprakash, Maureen A. Sullivan, Steven R. Gill Enterococcus faecalis enhances cell proliferation through hydrogen peroxide-mediated epidermal growth factor receptor activation. Infection and Immunity. Vol.80, No.10 (2012), 3545-3558. doi:10.1128/IAI.00479-12 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14261
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Title
Enterococcus faecalis enhances cell proliferation through hydrogen peroxide-mediated epidermal growth factor receptor activation
Abstract
Enterococcus faecalis is a member of the intestinal and oral microbiota that may affect the etiology of colorectal and oral cancers. The mechanisms by which E. faecalis may contribute to the initiation and progression of these cancers remain uncertain. Epidermal growth factor receptor (EGFR) signaling is postulated to play a crucial role in oral carcinogenesis. A link between E. faecalis and EGFR signaling in oral cancer has not been elucidated. The present study aimed to evaluate the association between E. faecalis and oral cancer and to determine the underlying mechanisms that link E. faecalis to EGFR signaling. We report the high frequency of E. faecalis infection in oral tumors and the clinical association with EGFR activation. Using human oral cancer cells, we support the clinical findings and demonstrate that E. faecalis can induce EGFR activation and cell proliferation. E. faecalis activates EGFR through production of H 2 O 2 , a signaling molecule that activates several signaling pathways. Inhibitors of H 2 O 2 (catalase) and EGFR (gefitinib) significantly blocked E. faecalis-induced EGFR activation and cell proliferation. Therefore, E. faecalis infection of oral tumor tissues suggests a possible association between E. faecalis infection and oral carcinogenesis. Interaction of E. faecalis with host cells and production of H 2 O 2 increase EGFR activation, thereby contributing to cell proliferation. © 2012, American Society for Microbiology.