Publication: Molecular docking studies and anti-enzymatic activities of thai mango seed kernel extract against snake venoms
Issued Date
2009-04-01
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14203049
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2-s2.0-66349117719
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules. Vol.14, No.4 (2009), 1404-1422
Suggested Citation
Jiraporn Leanpolchareanchai, Pimolpan Pithayanukul, Rapepol Bavovada, Patchreenart Saparpakorn Molecular docking studies and anti-enzymatic activities of thai mango seed kernel extract against snake venoms. Molecules. Vol.14, No.4 (2009), 1404-1422. doi:10.3390/molecules14041404 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27431
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Title
Molecular docking studies and anti-enzymatic activities of thai mango seed kernel extract against snake venoms
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Abstract
The ethanolic extract from seed kernels of Thai mango (MSKE) (Mangifera indica L. cv. 'Fahlun') (Anacardiaceae) and its major phenolic principle (pentagalloyl glucopyranose) exhibited dose-dependent inhibitory effects on enzymatic activities of phospholipase A2(PLA2), hyaluronidase and L-amino acid oxidase (LAAO) of Calloselasma rhodostoma (CR) and Naja naja kaouthia (NK) venoms by in vitro tests. The anti-hemorrhagic and anti-dermonecrotic activities of MSKE against both venoms were clearly supported by in vivo tests. Molecular docking studies indicated that the phenolic molecules of the MSKE could selectively bind to the active sites or their proximity, or modify conserved residues that are critical for the catalysis of PLA2, and selectively bind to the LAAO binding pocket of both CR and NK venoms and thereby inhibit their enzymatic activities. The results imply a potential use of MSKE against snake venoms. © 2009 by the authors.