Publication: Mitochondrial haplogroup background may influence Southeast Asian G11778A leber hereditary optic neuropathy
Issued Date
2011-06-01
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ISSN
15525783
01460404
01460404
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2-s2.0-80052370661
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Mahidol University
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SCOPUS
Bibliographic Citation
Investigative Ophthalmology and Visual Science. Vol.52, No.7 (2011), 4742-4748
Suggested Citation
Supannee Kaewsutthi, Nopasak Phasukkijwatana, Yutthana Joyjinda, Wanicha Chuenkongkaew, Bussaraporn Kunhapan, Aung Win Tun, Bhoom Suktitipat, Patcharee Lertrit Mitochondrial haplogroup background may influence Southeast Asian G11778A leber hereditary optic neuropathy. Investigative Ophthalmology and Visual Science. Vol.52, No.7 (2011), 4742-4748. doi:10.1167/iovs.10-5816 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12486
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Title
Mitochondrial haplogroup background may influence Southeast Asian G11778A leber hereditary optic neuropathy
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Abstract
Purpose. To investigate the role of mitochondrial DNA (mt DNA) background on the expression of Leber hereditary optic neuropathy (LHON) in Southeast Asian carriers of the G11778A mutation. Methods. Complete mtDNA sequences were analyzed from 53 unrelated Southeast Asian G11778A LHON pedigrees in Thailand and 105 normal Thai controls, and mtDNA haplogroups were determined. Clinical phenotypes were tested for association with mtDNA haplogroup, with adjustment for potential confounders such as sex and age at onset. Results. mtDNA subhaplogroup B was significantly associated with LHON. Follow-up analysis narrowed the association down to subhaplogroup B5a1 (P = 0.008). Survival analyses with Cox's proportional hazards modeling on 469 samples (91 affected and 378 unaffected), adjusted for sex and heteroplasmy, revealed that haplogroup B5a1 tended to increase the risk of visual loss, but the trend was not statistically significant. Conversely, haplogroup F, the second most common haplogroup in the control population, was the least frequent haplogroup in LHON. This negative association was narrowed down to subhaplogroup F1 (P = 0.00043), suggesting that haplogroup F1 confers a protective effect. The distributions of sex, age at onset and heteroplasmy were not significantly different among haplogroups. Conclusions. The specific mtDNA background B5a1 was significantly associated with Southeast Asian G11778A LHON and appeared to modify the risk of visual loss. © 2011 The Association for Research in Vision and Ophthalmology, Inc.