Publication: Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis
Issued Date
2015
Resource Type
Language
eng
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Mahidol University
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BioMed Central
Bibliographic Citation
BMC Anesthesiology. Vol. 15, (2015), 84
Suggested Citation
Sikarin Upala, Anawin Sanguankeo, Nitipong Permpalung Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis. BMC Anesthesiology. Vol. 15, (2015), 84. doi:10.1186/s12871-015-0063-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2673
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Title
Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis
Abstract
Background: A number of observational studies have found an association between low vitamin D levels and risk
of sepsis. We conducted a systematic review and meta-analysis to determine the overall estimate of risk.
Methods: This was a systematic review and meta-analysis conducted by online searches (CENTRAL, PubMed/MEDLINE,
and EMBASE) was registered in PROSPERO (CRD42014014767). Primary outcome was incidence, prevalence, relative risk
or odds ratio of having sepsis or bloodstream infection between patients with vitamin D deficiency and controls.
Results: The initial search yielded 647 articles. Twenty-one articles underwent full-length review and data were
extracted from 10 observational studies. Pooled odds ratio of sepsis in participants with vitamin D deficiency was
1.78 (95 % confidence interval [CI] = 1.55 to 2.03, p < 0.01) compared with controls in studies that reported participant
numbers and was 1.45 (95 % CI = 1.26 to 1.66, p < 0.01) in studies that reported an adjusted odds ratio of vitamin D
deficiency for developing sepsis. Statistical between-study heterogeneity was low (I2 = 0 % and 5 %, respectively).
Standardized mean difference of 25-hydroxyvitamin D levels in patients with sepsis and controls was −0.24
(95 % CI = −0.49 to 0.00, p = 0.05) and lower in the sepsis group compared with non-sepsis or control participants. The
statistical between-study heterogeneity (I2) was 0 %.
Conclusion: Vitamin D deficiency were associated with an increased susceptibility of sepsis.