Publication: Clinical characteristics and treatment outcomes for patients infected with Mycobacterium haemophilum
9
Issued Date
2019-01-01
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ISSN
10806059
10806040
10806040
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2-s2.0-85071470746
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Mahidol University
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SCOPUS
Bibliographic Citation
Emerging Infectious Diseases. Vol.25, No.9 (2019), 1648-1652
Suggested Citation
Pornboonya Nookeu, Nasikarn Angkasekwinai, Suporn Foongladda, Pakpoom Phoompoung Clinical characteristics and treatment outcomes for patients infected with Mycobacterium haemophilum. Emerging Infectious Diseases. Vol.25, No.9 (2019), 1648-1652. doi:10.3201/eid2509.190430 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/52083
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Title
Clinical characteristics and treatment outcomes for patients infected with Mycobacterium haemophilum
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Abstract
© 2019 Centers for Disease Control and Prevention (CDC). All rights reserved. Mycobacterium haemophilum is a nontuberculous mycobacterium that can infect immunocompromised patients. Because of special conditions required for its culture, this bacterium is rarely reported and there are scarce data for long-term outcomes. We conducted a retrospective study at Siriraj Hospital, Bangkok, Thailand, during January 2012-September 2017. We studied 21 patients for which HIV infection was the most common concurrent condition. The most common organ involvement was skin and soft tissue (60%). Combination therapy with macrolides and fluoroquinolones resulted in a 60% cure rate for cutaneous infection; adding rifampin as a third drug for more severe cases resulted in modest (66%) cure rate. Efficacy of medical therapy in cutaneous, musculoskeletal, and ocular diseases was 80%, 50%, and 50%, respectively. All patients with central nervous system involvement showed treatment failures. Infections with M. haemophilum in HIV-infected patients were more likely to have central nervous system involvement and tended to have disseminated infections and less favorable outcomes.