Publication: Characterization of sera from subjects infected with HIV-1 subtypes B and E in Thailand by antibody binding and neutralization
Issued Date
1998-12-01
Resource Type
ISSN
10779450
Other identifier(s)
2-s2.0-0032400920
Rights
Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.19, No.4 (1998), 315-320
Suggested Citation
S. Louisirirotchanakul, S. Beddows, R. Cheingsong-Popov, N. Shaffer, T. D. Mastro, P. Auewarakul, S. Likanonsakul, C. Wasi, J. Weber Characterization of sera from subjects infected with HIV-1 subtypes B and E in Thailand by antibody binding and neutralization. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.19, No.4 (1998), 315-320. doi:10.1097/00042560-199812010-00001 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18369
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Title
Characterization of sera from subjects infected with HIV-1 subtypes B and E in Thailand by antibody binding and neutralization
Abstract
The range and specificity of the humoral immune response to HIV-1 subtypes B and E was investigated in Thai samples. Sera from HIV-1-positive subjects, consisting of subtypes B (n = 24) and E (n = 138), were characterized in relation to the neutralization of primary isolates and T- cell line-adapted (TCLA) strains and binding to monomeric gp120, the CD4/gp120 binding site (BS), and V3 peptides. A subtype-specific pattern of antibody binding was observed with the exception of the CD4/gp120(MN) BS. Neutralization of TCLA strains (n = 4) was strongly type-specific (p = .002); however, neutralization of primary isolates (n = 8) was weak and group specific. Thus, the subtype specificity of B and E sera in the neutralization of TCLA strains, but not primary isolates, supports the dominance of the V3 region in TCLA virus neutralization but does no(support the distinction of subtypes B and E as discrete neutralization serotypes in Thailand.