Publication: Maoberry (Antidesma bunius) ameliorates oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet
Issued Date
2018-12-27
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ISSN
14726882
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2-s2.0-85059224925
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Mahidol University
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SCOPUS
Bibliographic Citation
BMC Complementary and Alternative Medicine. Vol.18, No.1 (2018)
Suggested Citation
Arunwan Udomkasemsab, Chattraya Ngamlerst, Poom Adisakwattana, Amornrat Aroonnual, Rungsunn Tungtrongchitr, Pattaneeya Prangthip Maoberry (Antidesma bunius) ameliorates oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet. BMC Complementary and Alternative Medicine. Vol.18, No.1 (2018). doi:10.1186/s12906-018-2400-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46115
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Title
Maoberry (Antidesma bunius) ameliorates oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet
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Abstract
© 2018 The Author(s). Backgound: Chronic fat-rich diets consumption is increased risk associated with cardiovascular diseases (CVD). Prevention or reduction the progression of cardiac tissue deterioration could benefit in CVD. This study aimed to examine the effects of maoberry (Antidesma bunius), a antioxidant-rich tropical fruit, supplementation on oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet (HFD). Methods: The male rats orally received HFD with maoberry extract doses of 0.38, 0.76 or 1.52 g/kg or simvastatin (10 mg/kg) for 12 weeks. At the end of the experimental period, the rats were fasted, euthanized and harvested for the hearts. Results: Significantly reduced oxidative stress (malondialdehyde levels) and enhanced antioxidant capacity (ferric-reducing activities) in cardiac tissues of the rats were found. Maoberry extract remarkably ameliorated the expressions of genes involved with pro-inflammatory such as the tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and endothelial nitric oxide synthase (eNOS). Conclusions: Our findings suggest that maoberry extract has remarkable effects on preventing progression of cardiac tissue deterioration at least through lowering oxidative stress and inflammation.