Publication:
ASSOCIATION OF OBSTRUCTIVE SLEEP APNEA WITH CENTRAL SEROUS CHORIORETINOPATHY AND CHOROIDAL THICKNESS: A Systematic Review and Meta-Analysis

dc.contributor.authorChris Y. Wuen_US
dc.contributor.authorTanawan Riangwiwaten_US
dc.contributor.authorPattara Rattanawongen_US
dc.contributor.authorBrooke L.W. Nesmithen_US
dc.contributor.authorAvnish Deobhaktaen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherUniversity of Hawaii at Manoaen_US
dc.contributor.otherIcahn School of Medicine at Mount Sinaien_US
dc.contributor.otherNew York Eye and Ear Infirmaryen_US
dc.date.accessioned2019-08-23T11:47:39Z
dc.date.available2019-08-23T11:47:39Z
dc.date.issued2018-09-01en_US
dc.description.abstractPURPOSE: Obstructive sleep apnea (OSA) has been associated with an array of ocular disorders. This systematic review aims to investigate the association of OSA with central serous chorioretinopathy (CSCR) and subfoveal choroidal thickness changes on enhanced depth imaging optical coherence tomography.METHODS: Systematic review and meta-analysis of all articles published up to November 2017 examining rate of OSA in patients with CSCR versus controls or examining subfoveal choroidal thickness measurements on enhanced depth imaging optical coherence tomography in patients with OSA versus controls. Pooled odds ratios and weighted mean difference with 95% confidence intervals (CIs) were calculated.RESULTS: For the CSCR/OSA analysis, 7,238 patients (1,479 with CSCR and 5,759 controls) from 6 studies were eligible. For the choroidal thickness/OSA analysis, 778 eyes of 778 patients (514 with OSA and 264 controls) from 9 studies were eligible. Patients with CSCR had a 1.56 increased odds of having OSA than controls (odds ratio, 1.56; 95% CI, 1.16-2.10). There was no statistically significant difference in choroidal thickness between mild OSA subjects and controls (weighted mean difference = -3.17; 95% CI, -19.10 to 12.76). Patients with moderate OSA (weighted mean difference = -24.14; 95% CI, -42.16 to -6.12) and severe OSA (weighted mean difference = -51.19; 95% CI, -99.30 to -3.08) had thinner choroidal thickness measurements than controls.CONCLUSION: In summary, our results suggest that patients with CSCR are more likely to have OSA, and that moderate/severe OSA is associated with smaller subfoveal choroidal measurements on enhanced depth imaging optical coherence tomography.en_US
dc.identifier.citationRetina (Philadelphia, Pa.). Vol.38, No.9 (2018), 1642-1651en_US
dc.identifier.doi10.1097/IAE.0000000000002117en_US
dc.identifier.issn15392864en_US
dc.identifier.other2-s2.0-85051587564en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/46400
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051587564&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleASSOCIATION OF OBSTRUCTIVE SLEEP APNEA WITH CENTRAL SEROUS CHORIORETINOPATHY AND CHOROIDAL THICKNESS: A Systematic Review and Meta-Analysisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051587564&origin=inwarden_US

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