Publication: Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood
Issued Date
2002-11-01
Resource Type
ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0036839058
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.186, No.9 (2002), 1371-1375
Suggested Citation
Sujittra Chaisavaneeyakorn, Julie M. Moore, Caroline Othoro, Juliana Otieno, Sansanee C. Chaiyaroj, Ya Ping Shi, Bernard L. Nahlen, Altaf A. Lal, Venkatachalam Udhayakumar Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood. Journal of Infectious Diseases. Vol.186, No.9 (2002), 1371-1375. doi:10.1086/344322 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20346
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Title
Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood
Abstract
Macrophage migration inhibitory factor (MIF) may play a role in immune responses to malaria during pregnancy by virtue of its ability to activate macrophages and to overcome the immunosuppressive effect of glucocorticoids. The present study investigated whether plasma MIF levels are altered in pregnant women with placental malaria (PM) and/or human immunodeficiency virus (HIV) infection. For the first time it is demonstrated that MIF levels in the intervillous blood (IVB) plasma were significantly elevated, compared with that in both peripheral plasma (500-fold) and cord plasma (4.6-fold; P < .01). IVB mononuclear cells also produced significantly higher levels of MIF, compared with that of peripheral blood mononuclear cells. PM was associated with increased levels of MIF in the IVB plasma (P < .02). Primigravid and secundigravid women had significantly higher levels of MIF in their IVB plasma than did multigravid women (P < .05). HIV infection did not significantly alter MIF levels in any site examined.